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☆ More people need transplants than there are organ donors. Pigs might offer a solution
▼ + stars: | 2024-01-30 | by ( Jen Christensen | ) edition.cnn.com time to read: +23 min

The need for more transplant organs is immense and growing. Researchers have transplanted genetically modified pig kidneys and hearts into people who were brain-dead to test whether they work in humans. Although Larry Faucette was too sick for a human heart transplant, University of Maryland doctors said he seemed physically strong enough for a genetically modified pig heart. It was more than a decade after the first heart transplant but long before such procedures became relatively routine. “We learned that the pig heart is an adequate substitute for a human heart.

Persons: Lawrence Faucette, Ann, he’d, ” Ann, Larry Faucette, Ann Faucette Ann, Larry, didn’t, ”, Robert Montgomery, “, Shelby Lum, ” Montgomery, Xenotransplantation, Art Caplan, Caplan, Babe ”, ” Caplan, They’re, eGenesis, people’s, Dr, Mike Curtis, Sanjay Gupta, ” Curtis, hasn’t, Julie O’Hara, Jim Parsons, Jayme Locke, couldn’t, Locke, Parsons, NYU —, Montgomery —, O’Hara, ” Locke, David Bennett Sr, Mary, David Jr, Bartley Griffith, Bennett, they’ve, Muhammad M, Mohiuddin, Larry Faucette’s, David Bennett’s, ” Griffith, xenotransplantation Ann Faucette, Wilbur, White’s, Ann Faucette, NYU ethicist Caplan, they’re, NYU’s Montgomery, UAB’s Locke, Steve Wood, ’ Curtis, “ I’m, it’s, ” O’Hara, Bennett’s, Larry Faucette —, ” Bennett’s, Faucette, who’d, Griffith, would’ve, Kate, Lucy, Nadia Kounang Organizations: CNN, Food and Drug Administration, University of Maryland, FDA, National Institute of Allergy, NYU Langone Transplant Institute, NYU Langone's Transplant, NYU Grossman School, Medicine’s Department of Population Health, “ Disney, University of Alabama, Transplant Institute, Parsons Family, Birmingham, NYU, University of Maryland School of Medicine, Doctors, University of Maryland Medical Center, Uno, UAB, CNN Health, NFL Locations: Frederick , Maryland, United States, Montgomery, “, Midwest, Yucatan, Maryland

☆ Second person to receive experimental pig heart transplant dies nearly six weeks after procedure
▼ + stars: | 2023-10-31 | by ( Nadia Kounang | ) edition.cnn.com time to read: +3 min

CNN —Lawrence Faucette, the second living person to receive a genetically modified pig heart in a transplant, has died six weeks after the experimental procedure. Griffith had performed the experimental surgery. Faucette, 58, was first admitted to UMMC on September 14 after experiencing symptoms of heart failure and underwent the experimental transplant six days later. His heart disease and pre-existing conditions made him ineligible for a traditional human heart transplant. In January 2022, the University of Maryland also performed the first such experimental surgery on 57-year-old David Bennett, who died two months following the surgery.

Persons: CNN — Lawrence Faucette, “ Mr, Faucette’s, Dr, Bartley Griffith, Griffith, UMMC, “, ” Faucette, ”, Ann Faucette, “ We’ve, ” Griffith, Doctors, Ann, “ Larry, Sanjay Gupta, David Bennett, Bennett Organizations: CNN, University of Maryland Medical Center, University of Maryland School of Medicine, CNN Health, University of Maryland Locations: UMMC

☆ Second Maryland Man to Receive an Altered Pig’s Heart Has Died
▼ + stars: | 2023-10-31 | by ( Roni Caryn Rabin | ) www.nytimes.com time to read: +1 min

A 58-year-old man with heart failure who received a new heart from a genetically modified pig died on Monday, nearly six weeks after receiving the pig organ, University of Maryland Medical Center officials announced on Tuesday. The first patient, 57-year-old David Bennett, died last year, two months after his transplant. He had developed multiple complications, and traces of a virus that infects pigs were found in his new heart. Both of the patients had terminal heart disease when they received the transplanted organs, and neither managed to recover sufficiently to leave the hospital. But while doctors said that Mr. Bennett did not show any signs of acute rejection of the new heart, which is the most significant risk in organ transplants, they said that Mr. Faucette’s transplanted heart had started to display some initial signs of rejection.

Persons: Lawrence Faucette, David Bennett, Mr, Bennett, Faucette’s Organizations: University of Maryland Medical Center Locations: Frederick, Md

☆ One couple packed up an RV and drove 1,300 miles to give birth in Virginia to escape the high Black maternal mortality rate in Texas
▼ + stars: | 2023-10-01 | by ( Brianna Holt | ) www.businessinsider.com time to read: +8 min

Two Black women crossed state lines to give birth since they lived in places with low healthcare ratings. AdvertisementAdvertisementFor Black women, both nationally and in Texas, those rates are disproportionately higher. To avoid becoming another statistic, more and more Black women are opting for home births, doulas, midwives, and birth assistants. Due to the high maternal mortality rate in the US, some Black women are turning to midwives. Perritt warned that crossing state lines, even for those who can afford it, will not address the Black maternal mortality crisis.

Persons: Mimi Evans, Evans, Sarah Reingewirtz, Jamila, Perritt, Erin Monk, Monk, she's Organizations: MediaNews, Los Angeles Daily, Getty, OB, Physicians, Reproductive, VCU Medical Center, SDI, University of Maryland Medical Center, University Hospital Locations: States, Houston, Texas, Richmond , Virginia, Chesterfield, Richmond, In Texas, United States, Virginia, Charlotte , North Carolina, Baltimore , Maryland, Carolina, Maryland, Charlotte

CNN —An 18-year-old woman and a 20-year-old man were killed and 28 others injured in a mass shooting at a Baltimore block party, officials said. Nine people were transported from the scene to hospitals and 20 people walked into hospitals in the area. The 18-year-old was pronounced dead on the scene and the 20-year-old was pronounced dead at a hospital, police said. Police received multiple calls after 12:30 a.m., and arrived to find one woman dead and another nine people suffering from gunshot wounds, according to Baltimore Police Acting Commissioner Richard Worley. There is no information on suspects or a motive at this time, but investigators are “working an extensive crime scene,” Worley said.

Persons: Adams Cowley, Michael Schwartzberg, Richard Worley, ” Worley, Baltimore Mayor Brandon Scott, ” Scott, “, ”, CNN’s Victor Blackwell, Amara Walker, Scott, ” “ Organizations: CNN, Adams Cowley Shock Trauma, University of Maryland Medical Center, University of Maryland Medical, Police, Baltimore Police, Baltimore Mayor Locations: Baltimore, Brooklyn

☆ Pig’s Heart Took Longer to Generate a Beat in Transplant Patient
▼ + stars: | 2022-10-31 | by ( Amy Dockser Marcus | ) www.wsj.com time to read: 1 min

The transplant took place in January, and the recipient died in March. A genetically modified pig heart transplanted into a severely ill person took longer to generate a heartbeat than those of typical pig or human hearts, research showed, another potential challenge for doctors aiming to conduct clinical trials of pig-organ transplants. Doctors took daily electrocardiograms of David Bennett , a 57-year-old handyman and father of two who received a gene-edited pig heart in an experimental surgery at the University of Maryland Medical Center in Baltimore in January. Mr. Bennett died in March from heart failure, but doctors still aren’t sure why the pig heart thickened and lost its pumping ability.

☆ About 17 Americans die waiting for transplants each day. Scientists are trying to make more organs in 5 creative ways.
▼ + stars: | 2022-10-18 | by ( Morgan Mcfall-Johnsen | ) www.businessinsider.com time to read: +11 min

Courtesy of Leilani GrahamIf pig organs turn out to be just as effective as human organs, she added, "That is more appealing to me than using marginal donors." If the technique works for human organs in the future, it could allow clinicians to preserve many more organs for donation after death. Changing organs' blood typeEnzymes are delivered to a lung inside a perfusion machine at Dr. Marcelo Cypel’s lab. Growing synthetic organs from stem cellsResearcher Stormy Chamberlain holds a tray of stem cells at the University of Connecticut's Stem Cell Institute. Hanna started a company called Renewal Bio to pursue the possibility of turning stem cells into organs for transplants.

☆ 5 cutting-edge medical experiments could expand our organ supply, from gene-edited pigs to artificial embryos
▼ + stars: | 2022-09-24 | by ( Morgan Mcfall-Johnsen | ) www.businessinsider.com time to read: +10 min

Courtesy of Leilani GrahamIf pig organs turn out to be just as effective as human organs, she added, "That is more appealing to me than using marginal donors." While much of the shortage is driven by imperfect logistics and bureaucracy rather than supply, cutting-edge research could make organs — human, pig, or synthetic — more accessible in Graham's lifetime. If the technique works for human organs in the future, it could allow clinicians to preserve many more organs for donation after death. Changing organs' blood typeEnzymes are delivered to a lung inside a perfusion machine at Dr. Marcelo Cypel’s lab. Growing synthetic organs from stem cellsResearcher Stormy Chamberlain holds a tray of stem cells at the University of Connecticut's Stem Cell Institute.

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